A 2025 Tools for Practice review1 noted that about 40% of people with fibromyalgia on pregabalin 300-600mg/day experience a meaningful reduction in pain (pain reduced by ≥30%) versus 30% on placebo at 8-14 weeks.
Lower doses (example: 150mg) may not be effective; however, higher doses cause more harm, with up to ~30% of people stopping due to side effects (versus 10% on placebo).
Based on one small randomised, controlled trial (RCT), gabapentin is also effective.
As published in NZ Doctor and Research Review
