High dose vitamin D supplementation does not prevent CVD

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High dose vitamin D supplementation does not prevent CVD  

In this New Zealand randomized clinical trial of 5,108 community participants,1 the cumulative incidence of cardiovascular disease for a median follow-up period of 3.3 years was 11.8% among participants given vitamin D monthly and 11.5% among those given placebo. 

The dosage regime was oral vitamin D3 in an initial dose of 200 000 IU, (5 mg or 4 Cholecalciferol tablets in NZ) followed by monthly doses of 100 000 IU, (2 NZ tablets) or placebo for a median of 3.3 years. Those with a low serum level at baseline found similar results. 

Cohort studies have reported increased incidence of cardiovascular disease (CVD) among individuals with low vitamin D status.

To date, randomized clinical trials of vitamin D supplementation have not found an effect, possibly because of using too low a dose of vitamin D.


  1. Scragg R et al. Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study: A Randomized Clinical Trial. JAMA Cardiology. Published online April 5, 2017. Click here 

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      As published in NZ Doctor 5/7/2017