Oral propranolol effective for strawberry naevus

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Goodfellow Gems

"Oral propranolol effective for strawberry naevus"

For the first time, a large, randomised trial has shown a benefit from oral propranolol for infantile haemangioma (strawberry naevus).1,2 The natural history is to present shortly after birth, and for flat lesions to improve with oral propranolol treatment over 18 months while bulky ones tend to persist.

After 6 months of treatment, 60% were completely healed or nearly completely healed versus 4% in the placebo group. The usual dosing was 1mg/kg of bodyweight per day for the first week increasing to 3mg/kg by week 3. There were infrequent issues of bronchospasm, bradycardia, hypotension and hypoglycaemia, but these occurred in both groups with the only serious adverse event being a bradycardia in the propranolol group in the context of enterocolitis.

  1. http://dermnetnz.org/
  2. http://bit.ly/1ACqn2C (NEJM February 2015)

Gems are chosen by the Goodfellow director Dr. Bruce Arroll to be either practice changing or practice maintaining. The information is educational and not clinical advice.

As published in NZ Doctor 15/04/2015