A systematic review in The Lancet1 outlined the cardiometabolic issues with antidepressants.
There were a few surprises:
- None had significant QT interval issues.
- Systolic BP went up with amitriptyline and fluoxetine and down with nortriptyline.
- Weight loss was observed with bupropion, sertraline, citalopram, paroxetine, and venlafaxine.
- Weight gain was found with amitriptyline 1.6 kg and mirtazapine 0.87 kg.
- Heart rate increased (beats per minute) to 13.77 for nortriptyline, 9.25 for amitriptyline, and 9.44 for imipramine.
