Those with diabetes are at risk of infection of wounds of the feet and legs, as well as delayed wound healing and development of ulcers, due to peripheral neuropathy and peripheral arterial disease. This can potentially lead to gangrene and lower extremity amputation.

Patients are often unaware of damage occurring from injuries or pressure from shoes due to impaired or complete loss of sensation.

For this reason, regular foot checks by a health professional and good daily foot care are an important part of the prevention and management of diabetic foot disease.