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Vildagliptin – now fully funded gliptin for type 2 diabetes

Vildagliptin, a DPP-4 class of medication, is now fully funded in NZ for type 2 diabetes. It is recommended as a second or third line oral anti-hyperglycaemic, added to metformin treatment.1

It is a 50 mg tablet and is also in combination with 850 mg or 1 gm of metformin. Metformin is the first choice. If contraindicated then consider Vildagliptin, a sulphonylurea or pioglitazone.


  • is not associated with weight gain
  • has a low risk of hypoglycaemia
  • is not recommended in pregnancy or breastfeeding
  • is associated with a small increased risk of pancreatitis (0.13%)
  • should not be started, and should be withdrawn if persisting levels of AST or ALT greater than 3x upper limit of normal
  • is dosed twice daily but if eGFR < 50 ml/min/1.73m2 reduce to once daily
  • side effects are mild – discontinuation rates ≤ 5%
  • is not recommended in severe CHF (NYHA class IV).

This Gem has been checked by Dr Linda Bryant, Clinical Pharmacist.

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