Alzheimer's Disease: Metabolic strategies to slow and reverse progression
Dr Matthew Phillips discusses metabolic strategies for the treatment of Alzheimer’s disease, including both fasting and the ketogenic diet. He also discusses results from his Waikato trials.
Topics:
- 00:00 intro
- 01:35 impaired brain energy metabolism
- 02:52 prevalence in NZ
- 04:13 What is meant by the phrase “type 3 diabetes”
- 05:58 new randomized crossover trial in the Waikato
- 08:58 A modified keto diet
- 13:40 How difficult was adherence
- 15:18 Prescribing keto or Low Carbohydrate Diet may be a bit scary
- 18:21 Can we measure LDL subfractions in NZ, and should we be doing this?
- 19:06 Trial results
- 20:27 Can we, and should we, be telling our patients w AD to go keto full time?
- 23:30 How fasting differs from Keto diets
- 26:40 What does the fast involve?
- 28:50 Has Alzheimer's and fasting been studied.
- 30:42 Take-home messages
Take-home messages
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Resources
- Metabolic Neurologist - Resources from Matthew Phillips
- Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease - Alzheimer's Research & Therapy (2021)
- NZ Dementia Foundation
- Alzheimers New Zealand
- New Zealand Framework for Dementia Care MZ MOH (2013)
- Alzheimer’s disease Health Navigator NZ patient resources
Presenter
Matthew Phillips
Clinical and Research Neurologist
Dr Matthew Phillips is a full-time clinical and research neurologist at Waikato Hospital, Hamilton. His foremost passion is to explore the potential feasibility, safety, and efficacy of metabolic strategies, particularly fasting and ketogenic diets, in creating alternate metabolic states that may improve not only the symptoms, but also function and quality of life, for people with a variety of difficult disorders. In 2021, Matt and his dedicated team published the world’s first randomized trial of a ketogenic diet in Alzheimer’s Disease.